Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877244 | 0.90 | SMN1; SMN2 (0.64) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL14380379 | 0.84 | HDAC8 (0.61) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL13670598 | 0.79 | KDM4E (0.63) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL6606979 | 0.78 | L3MBTL1 (0.79) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL9877306 | 0.78 | ALOX5 (0.82) | FFAR1ALOX5HDAC1MAPTHDAC2 | |
| SCHEMBL4453789 | 0.77 | L3MBTL1 (0.77) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL4559590 | 0.76 | SMN1; SMN2 (0.67) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL3809685 | 0.76 | SMN1; SMN2 (0.79) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL9876864 | 0.76 | HDAC3 (0.67) | ALOX5HDAC1HDAC8HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL8531645 | 0.76 | KDM4E (0.67) | L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |