Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877249 | 0.90 | L3MBTL1 (0.58) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL8534233 | 0.82 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL2632728 | 0.79 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL8534650 | 0.79 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| Fenbufen SCHEMBL11329267 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| Fenbufen SCHEMBL25117 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL9877206 | 0.78 | ALOX5 (0.63) | FFAR1KMT2AMEN1ALOX5 | |
| Hydrochloric Acid SCHEMBL8531645 | 0.78 | KDM4E (0.67) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL14380379 | 0.78 | HDAC8 (0.61) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A | |
| SCHEMBL3733726 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAFFAR1CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |