Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 4/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | GLB1 | P16278 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AGL | P35573 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL5475929 | 0.95 | — | — | |
| Pyrrolidine SCHEMBL28301447 | 0.84 | — | — | |
| Piperazine SCHEMBL699478 | 0.81 | ALDH1A1 (0.57) | HIF1AMAPTPDE4AKDRTSHR | |
| 1,6-Hexanediol SCHEMBL5079261 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRTSHR | |
| Piperidine SCHEMBL28046835 | 0.81 | ALDH1A1 (0.64) | HIF1AMAPTPDE4AKDRTSHR | |
| Piperazine SCHEMBL3344476 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRTSHR | |
| Piperazine SCHEMBL9506704 | 0.78 | ALDH1A1 (0.50) | HIF1AMAPTPDE4AKDRTSHR | |
| Piperazine SCHEMBL1485419 | 0.78 | — | — | |
| Piperazine SCHEMBL22092466 | 0.75 | ALDH1A1 (0.46) | HIF1AMAPTPDE4AKDRTSHR | |
| Ethylene Glycol SCHEMBL3070437 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106749099-A | A kind of preparation method of ethylene glycol Piperazine Synthesis by Gas-Solid Catalyzed and catalyst | 陕西延长石油（集团）有限责任公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106749099-A | A kind of preparation method of ethylene glycol Piperazine Synthesis by Gas-Solid Catalyzed and catalyst | 陕西延长石油（集团）有限责任公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106749099-A | A kind of preparation method of ethylene glycol Piperazine Synthesis by Gas-Solid Catalyzed and catalyst | 陕西延长石油（集团）有限责任公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106749099-A | A kind of preparation method of ethylene glycol Piperazine Synthesis by Gas-Solid Catalyzed and catalyst | 陕西延长石油（集团）有限责任公司 | 2017-05-31 | — | — | CN | disclosed |
| EP-0207083-B1 | COMPOSITIONS OF POLYCYCLOALKENYL-TERMINATED, UNSATURATED POLYESTERS OR POLYESTERAMIDES AND VINYL-REACTIVE PLASTICIZERS THEREFOR | THE DOW CHEMICAL COMPANY (US) | 1991-12-18 | — | — | EP | disclosed |
| US-4777209-A | IMPROVED DUCTILITY, ELONGATION AND TENSILE AND IMPACT STRENGTHS | THE DOW CHEMICAL COMPANY (US) | 1988-10-11 | — | — | US | disclosed |
| EP-0248934-A1 | Polymer concrete compositions containing water absorbent polymers | THE DOW CHEMICAL COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |
| WO-1987004442-A1 | POLYMER MODIFIED UNSATURATED POLYESTER OR POLYESTERAMIDE RESINS AND POLYMER CONCRETE MADE THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0207083-A4 | COMPOSITIONS OF POLYCYCLOALKENYL-TERMINATED, UNSATURATED POLYESTERS OR POLYESTERAMIDES AND VINYL-REACTIVE PLASTICIZERS THEREFOR. | DOW CHEMICAL CO (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0207083-A1 | COMPOSITIONS OF POLYCYCLOALKENYL-TERMINATED, UNSATURATED POLYESTERS OR POLYESTERAMIDES AND VINYL-REACTIVE PLASTICIZERS THEREFOR. | DOW CHEMICAL CO (US) | 1987-01-07 | — | — | EP | disclosed |
| US-4611015-A | POLYESTERS, POLYAMIDES, UNSATURATED MONOMERS | THE DOW CHEMICAL COMPANY (US) | 1986-09-09 | — | — | US | disclosed |
| WO-1986003757-A1 | COMPOSITIONS OF POLYCYCLOALKENYL-TERMINATED, UNSATURATED POLYESTERS OR POLYESTERAMIDES AND VINYL-REACTIVE PLASTICIZERS THEREFOR | THE DOW CHEMICAL COMPANY (US) | 1986-07-03 | — | — | WO | disclosed |