Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 4/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.31 |
| ▸ | GLB1 | P16278 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL27274629 | 0.96 | — | — | |
| Piperidine SCHEMBL676507 | 0.84 | ALDH1A1 (0.53) | ALDH1A1TSHRCXCR4SMN1; SMN2 | |
| Sulfuric Acid SCHEMBL28872449 | 0.82 | TSHR (0.44) | ALDH1A1TSHRKDM4E | |
| Piperazine SCHEMBL2882663 | 0.81 | HIF1A (0.55) | ALDH1A1HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL14739784 | 0.81 | HIF1A (0.55) | ALDH1A1HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL9877421 | 0.81 | HIF1A (0.55) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL5946683 | 0.81 | HIF1A (0.55) | ALDH1A1HIF1AMAPTPDE4AKDR | |
| Morpholine SCHEMBL28011699 | 0.80 | KDM4E (0.55) | ALDH1A1TSHRSMN1; SMN2GAAKDM4E | |
| Piperazine SCHEMBL3905641 | 0.77 | HIF1A (0.50) | ALDH1A1HIF1AMAPTPDE4AKDR | |
| Ethylenediamine SCHEMBL1030825 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153064-A | Method for synthesizing piperazine and derivatives of piperazine through monoethanolamine gas-solid phase catalysis | XIAN MODERN CHEMISTRY RES INST | 2015-12-16 | — | — | CN | claimed |
| CN-109890366-A | Combination medicine for treating cardiovascular diseases and preparation and use methods thereof | 美进医药公司 | 2019-06-14 | — | — | CN | disclosed |
| EP-3430064-A1 | WASHING- AND CLEANING-ACTIVE POLYMER FILMS, PROCESS FOR THE PRODUCTION THEREOF AND USE THEREOF | BASF SE (DE) | 2019-01-23 | — | — | EP | disclosed |
| CN-104258725-B | Use particle capture CO comprising biocatalyzer2method | 二氧化碳处理公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105153064-A | Method for synthesizing piperazine and derivatives of piperazine through monoethanolamine gas-solid phase catalysis | XIAN MODERN CHEMISTRY RES INST | 2015-12-16 | — | — | CN | disclosed |
| WO-2012025190-A1 | ELECTROCHEMICALLY-GATED TRANSISTOR AND A METHOD FOR ITS MANUFACTURE | Karlsruher Institut für Technologie (DE) | 2012-03-01 | — | — | WO | disclosed |
| EP-2423965-A1 | Electrochemically-gated transistor and a method for its manufacture | Karlsruher Institut für Technologie (DE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2000033654-A1 | USE OF PROTEASE INHIBITORS TO MODULATE CELLULAR PATHWAYS, IMMUNITY AND THERAPIES ASSOCIATED THEREWITH | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2000-06-15 | — | — | WO | disclosed |
| CN-1045098-A | Process for preparing linear chain-extended polyalkylenepolyamines | DOW CHEMICAL CO (US) | 1990-09-05 | — | — | CN | disclosed |