Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424180 | 0.77 | LMNA (0.53) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL7379441 | 0.76 | LMNA (0.59) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL9566532 | 0.75 | DHFR (0.73) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL30083980 | 0.74 | LMNA (0.58) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL6534828 | 0.73 | LMNA (0.62) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL18764323 | 0.72 | MAPT (0.63) | NR4A2MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4302606 | 0.71 | MAOB (0.50) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL4302609 | 0.71 | MAOB (0.53) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL7379345 | 0.71 | PRMT5 (0.59) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 | |
| SCHEMBL254671 | 0.70 | LMNA (0.88) | CYP1A2LMNAPTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981967-A | Pyrimidine compounds and their use as liquid crystals | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| US-4831143-A | Pyrimidine compound | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| US-4804759-A | Pyrimidine compound | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1989-02-14 | — | — | US | disclosed |
| US-4786730-A | Pyrimidine compound | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1988-11-22 | — | — | US | disclosed |