Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877735 | 0.93 | PTGIR (0.48) | PTGIRADRB3SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL9877935 | 0.84 | PTGIR (0.53) | PTGIRADRB3SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10359077 | 0.82 | PTGIR (0.49) | PTGIRADRB3SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9877283 | 0.82 | PTGIR (0.51) | PTGIRADRB3SMN1; SMN2RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL9877187 | 0.81 | PTGIR (0.48) | PTGIRADRB3SMN1; SMN2ALDH1A1TP53 | |
| Water SCHEMBL9877241 | 0.81 | LMNA (0.51) | PTGIRADRB3SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10359758 | 0.80 | PTGIR (0.49) | PTGIRADRB3SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL9876977 | 0.80 | MEN1 (0.52) | PTGIRADRB3ALDH1A1TP53GAA | |
| SCHEMBL9876879 | 0.79 | ALDH1A1 (0.48) | PTGIRALDH1A1RAB9ATP53GAA | |
| SCHEMBL9877410 | 0.79 | PTGIR (0.48) | PTGIRADRB3ALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |