Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588833 | 0.77 | PPARG (0.44) | MEN1KMT2AMAPTTHRBCCR2 | |
| SCHEMBL4589034 | 0.77 | PPARG (0.44) | MEN1KMT2AMAPTCCR2SOS1 | |
| SCHEMBL4845324 | 0.77 | HTR2C (0.41) | MEN1KMT2AMAPTCCR2SOS1 | |
| SCHEMBL9167916 | 0.76 | SLC6A4 (0.44) | MEN1KMT2AMAPTCCR2SOS1 | |
| SCHEMBL2930491 | 0.76 | CCR2 (0.51) | MEN1KMT2AMAPTCCR2SOS1 | |
| SCHEMBL9879636 | 0.74 | SIGMAR1 (0.74) | PPARGPPARAHTR7 | |
| SCHEMBL6320725 | 0.74 | LMNA (0.55) | MEN1KMT2AMAPTLMNAPOLB | |
| SCHEMBL10975299 | 0.74 | HTR2C (0.43) | MEN1KMT2AMAPTCCR2SOS1 | |
| SCHEMBL4587602 | 0.74 | SOS1 (0.49) | MEN1KMT2AMAPTCCR2SOS1 | |
| Hydrochloric Acid SCHEMBL9992562 | 0.73 | LMNA (0.54) | MEN1KMT2AMAPTTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008200-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AS ACTIVE AGENTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1991-06-13 | — | — | WO | claimed |