Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.34 |
| ▸ | RELA | Q04206 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.33 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109650 | 0.92 | FFAR4 (0.35) | KDM1ANR1I3SCN9ALMNAPOLB | |
| SCHEMBL6762742 | 0.84 | BACE1 (0.41) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL6832201 | 0.84 | BACE1 (0.41) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL6762623 | 0.84 | BACE1 (0.41) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL7423564 | 0.81 | KYAT1 (0.46) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL6762670 | 0.80 | AADAT (0.39) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL3781776 | 0.80 | CCKBR (0.39) | KDM1AKYAT1KYAT3AADAT | |
| SCHEMBL6763949 | 0.79 | BACE1 (0.39) | KDM1AGAANFKB1NFKB2RELA | |
| SCHEMBL7420732 | 0.78 | KYAT1 (0.42) | KDM1AGAALMNAKYAT1KYAT3 | |
| SCHEMBL3773910 | 0.76 | PYGL (0.39) | NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487104-B2 | KAT II inhibitors | PFIZER INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8487104-B2 | KAT II inhibitors | PFIZER INC. (US) | 2013-07-16 | — | — | US | disclosed |
| WO-2012073146-A1 | KAT II INHIBITORS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| US-20120142729-A1 | KAT ll INHIBITORS | PFIZER INC. | 2012-06-07 | — | — | US | disclosed |
| US-20120142729-A1 | KAT ll INHIBITORS | PFIZER INC. | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142729-A1 | KAT ll INHIBITORS | KAT7, KAT2A, KATNA1 | KDM1A 145/4885NR1I3 326/4885GAA 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.