Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988797 | 1.00 | LMNA (0.44) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2933889 | 0.89 | HTT (0.56) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL988312 | 0.88 | LMNA (0.50) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL988023 | 0.83 | ALDH1A1 (0.60) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2169885 | 0.79 | MAPT (0.59) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2169236 | 0.79 | TSHR (0.53) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2169225 | 0.79 | TSHR (0.53) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2169882 | 0.79 | MAPT (0.59) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2902973 | 0.77 | LMNA (0.60) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL27612062 | 0.74 | RAB9A (0.48) | LMNAMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | disclosed |