Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988803 | 0.80 | CYP2A6 (0.53) | CYP2A6CYP19A1AXLPBRM1MKNK1 | |
| SCHEMBL1201737 | 0.77 | LMNA (0.42) | CYP19A1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16834631 | 0.76 | CYP2A6 (0.41) | CYP2A6PIM1CYP3A4 | |
| SCHEMBL1316597 | 0.76 | RAB9A (0.48) | ALDH1A1 | |
| SCHEMBL988804 | 0.73 | — | — | |
| SCHEMBL18422490 | 0.72 | CYP11B2 (0.43) | — | |
| SCHEMBL6544558 | 0.71 | MAPT (0.54) | CYP19A1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL5541082 | 0.71 | SREBF2 (0.41) | ALDH1A1 | |
| SCHEMBL12614991 | 0.71 | CYP1A2 (0.39) | CYP19A1ALDH1A1CYP1A2 | |
| SCHEMBL11297134 | 0.71 | GRM2 (0.37) | ATMALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | claimed |
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | disclosed |