Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 12/20 | 1.00 |
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | OPRK1 known ✓ | P41145 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocodone SCHEMBL277572 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL1560734 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL10440385 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL6744988 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL12513789 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL13091350 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL8765132 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL12369421 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL21335350 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL101731 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10849981-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KemPham, Inc. (US) | 2020-12-01 | — | — | US | disclosed |
| US-10654863-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-10577376-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| EP-3560336-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | Kempharm, Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-2448407-B1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | KEMPHARM INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-10358452-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | KEMPHARM, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10351573-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | KEMPHARM, INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190160175-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | ALTER DOMUS (US) LLC | 2019-05-30 | — | — | US | disclosed |
| US-20180177883-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | ALTER DOMUS (US) LLC | 2018-06-28 | — | — | US | disclosed |
| US-20180104352-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2018-04-19 | — | — | US | disclosed |
| US-20090117054-A1 | SUBLINGUAL SPRAY FOR THE TREATMENT OF PAIN | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2009-05-07 | — | — | US | disclosed |
| US-20080207906-A1 | Synthetic Route to 14-Hydroxyl Opiates Through 1-Halo-Thebaine or Analogs | MALLINCKRODT ENTERPRISES LLC | 2008-08-28 | — | — | US | disclosed |
| US-20080207906-A1 | Synthetic Route to 14-Hydroxyl Opiates Through 1-Halo-Thebaine or Analogs | MALLINCKRODT ENTERPRISES LLC | 2008-08-28 | — | — | US | disclosed |
| EP-1233966-B1 | HYDROMORPHINONE AND HYDROCODEINONE COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | ABBOTT LAB (US) | 2008-07-30 | — | — | EP | disclosed |
| US-7399858-B2 | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof | MALLINCKRODT INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-7399858-B2 | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof | MALLINCKRODT INC. (US) | 2008-07-15 | — | — | US | disclosed |
| WO-2008073390-A2 | PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE | MALLINCKRODT INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073389-A2 | PREPARATION OF HEXAHYDROISOQUINOLINES FROM DIHYDROISOQUINOLINES | MALLINCKRODT INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008036172-A1 | PREPARATION OF SUBSTITUTED MORPHINAN-6-ONES AND SALTS AND INTERMEDIATES THEREOF | MALLINCKRODT INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| EP-1810973-A1 | 6-monoacetylmorphine derivatives useful in immunoassay | Roche Diagnostics GmbH (DE) | 2007-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351573-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | CYP2B6, CYP3A43, CYP2D6 | OPRD1 34/4885OPRM1 5/4885OPRK1 20/4885 |
| US-10654863-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-20190160175-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-20180104352-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-20180177883-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-10358452-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | CYP2B6, CYP3A43, CYP2D6 | OPRD1 34/4885OPRM1 5/4885OPRK1 20/4885 |
| US-20080207906-A1 | Synthetic Route to 14-Hydroxyl Opiates Through 1-Halo-Thebaine or Analogs | OPRK1, OPRM1, OPRD1 | OPRD1 3/4885OPRM1 2/4885OPRK1 1/4885 |
| US-10577376-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-10849981-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | OPRD1 29/4885OPRM1 19/4885OPRK1 4/4885 |
| US-20090117054-A1 | SUBLINGUAL SPRAY FOR THE TREATMENT OF PAIN | ALG3, SYMPK, OPRL1 | OPRD1 158/4885OPRM1 10/4885OPRK1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.