Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.37 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | PPARD | Q03181 | 7/20 | 0.37 |
| ▸ | PPARA | Q07869 | 7/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28473664 | 0.89 | CES2 (0.44) | CES2GPR84PPARGPPARDPPARA | |
| SCHEMBL28701284 | 0.80 | TSHR (0.35) | TSHRALDH1A1ESR1 | |
| SCHEMBL141054 | 0.79 | CES2 (0.38) | CES2AKR1B1GPR84PPARGPPARD | |
| SCHEMBL28586640 | 0.78 | GGPS1 (0.41) | CES2TSHR | |
| SCHEMBL28884013 | 0.78 | CES2 (0.41) | CES2GPR84PPARGPPARDPPARA | |
| SCHEMBL141053 | 0.77 | MEN1 (0.40) | CES2MEN1KMT2A | |
| SCHEMBL9246561 | 0.77 | CES2 (0.41) | CES2AKR1B1GPR84PPARGPPARD | |
| SCHEMBL9246564 | 0.76 | AKR1B1 (0.40) | CES2AKR1B1GPR84PPARGPPARD | |
| SCHEMBL7937643 | 0.76 | MEN1 (0.37) | CES2MEN1KMT2A | |
| SCHEMBL8025698 | 0.76 | TSHR (0.32) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 334 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595362-B2 | Polypropylene resin composition with excellent flame retardancy and formability | HYUNDAI MOTOR COMPANY (KR) | 2026-04-07 | — | — | US | claimed |
| US-12428509-B2 | Copolymerized PVDF resin for lithium ion battery binders and its preparation method | ZHIEJIANG QUZHOU JUSU CHEMICAL INDUSTRY CO., LTD (CN) | 2025-09-30 | — | — | US | claimed |
| CN-119639076-B | Submerged super-amphiphobic polymer porous material and preparation method and application thereof | 西南石油大学 | 2025-05-06 | — | — | CN | claimed |
| CN-119920821-A | Electrode plate, preparation method, lithium ion battery, diaphragm-free battery and all-solid-state battery | 重庆太蓝新能源有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-119841989-A | Preparation method and application of polyvinylidene fluoride resin | 万华化学集团股份有限公司 | 2025-04-18 | — | — | CN | claimed |
| CN-119639076-A | Submerged super-amphiphobic polymer porous material and preparation method and application thereof | 西南石油大学 | 2025-03-18 | — | — | CN | claimed |
| CN-119050489-A | Preparation method of high-voltage lithium battery with flame-retardant polymer solid electrolyte | 路华置富电子(深圳)有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-118360021-A | Dual-curing polarity-adjustable polyurethane hot melt adhesive and preparation method thereof | 浙江拓锐新材料科技有限公司 | 2024-07-19 | — | — | CN | claimed |
| CN-118240247-A | Polyimide film and preparation method thereof | 中国乐凯集团有限公司 | 2024-06-25 | — | — | CN | claimed |
| CN-118063686-A | Turbidity-removing and decoloring double-functional cationic polyacrylamide flocculant and preparation method and application thereof | 华南理工大学 | 2024-05-24 | — | — | CN | claimed |
| CN-110938266-A | Preparation method of PVC composite material | 龙吉松 | 2020-03-31 | — | — | CN | claimed |
| CN-108623716-B | Polymethyl methacrylate-carbon nanotube composite material and method for improving thermal stability thereof | 天津大学 | 2020-03-27 | — | — | CN | claimed |
| CN-108623737-B | Polymethyl methacrylate-carbon nanotube composite material and method for improving mechanical property thereof | 天津大学 | 2020-03-27 | — | — | CN | claimed |
| CN-110627946-A | Polymethyl methacrylate-trimethylvinyl benzylammonium chloride-graphene oxide composite material and preparation method thereof | 天津大学 | 2019-12-31 | — | — | CN | claimed |
| CN-110628157-A | Polymethyl methacrylate-trimethylvinyl benzylammonium chloride-carbon nanotube composite material and preparation method thereof | 天津大学 | 2019-12-31 | — | — | CN | claimed |
| CN-110627939-A | Polystyrene-4-cyanostyrene-reduced graphene oxide composite material and preparation method thereof | 天津大学 | 2019-12-31 | — | — | CN | claimed |
| CN-110628144-A | Polystyrene-2-vinylnaphthalene-reduced graphene oxide composite material and preparation method thereof | 天津大学 | 2019-12-31 | — | — | CN | claimed |
| US-20190300777-A1 | Phase Transition Material Fluid and Proppant Formed Therefrom | PETROCHINA COMPANY LIMITED (CN) | 2019-10-03 | — | — | US | claimed |
| EP-2883599-A2 | Polymer resin composition for preparing hollow fiber membrane, preparation method of hollow fiber membrane, and hollow fiber membrane | Lotte Chemical Corporation of (Sindaebang-dong) (KR) | 2015-06-17 | — | — | EP | claimed |
| US-20150144551-A1 | POLYMER RESIN COMPOSITION FOR PREPARING HOLLOW FIBER MEMBRANE, PREPARATION METHOD OF HOLLOW FIBER MEMBRANE, AND HOLLOW FIBER MEMBRANE | LOTTE CHEMICAL CORPORATION (KR) | 2015-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595362-B2 | Polypropylene resin composition with excellent flame retardancy and formability | PFKFB1, PF4, PFKFB4 | CES2 3499/4885AKR1B1 1428/4885GPR84 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.