Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172614 | 1.00 | CHRM5 (0.43) | CHRM5ADRA2CACHECHRM2CHRM4 | |
| SCHEMBL14665103 | 0.96 | CHRM5 (0.48) | CHRM5ADRA2CACHECHRM2CHRM4 | |
| SCHEMBL16480436 | 0.92 | MAPK1 (0.36) | CHRM5ADRA2CACHECHRM2CHRM1 | |
| SCHEMBL12717512 | 0.92 | MAPK1 (0.36) | CHRM5ADRA2CACHECHRM2CHRM1 | |
| SCHEMBL13560145 | 0.85 | CHRM5 (0.41) | CHRM5ADRA2CACHECHRM2CHRM4 | |
| SCHEMBL9893057 | 0.83 | HSD11B1 (0.41) | CHRM2CHRM1MAPK1KMT2AALDH1A1 | |
| SCHEMBL13560148 | 0.82 | CYP1A2 (0.52) | CHRM5ADRA2CACHECHRM2CHRM4 | |
| SCHEMBL27126557 | 0.82 | GBA1 (0.40) | CHRM5ADRA2CCHRM2CHRM1MAPK1 | |
| SCHEMBL4586403 | 0.80 | CHRM5 (0.43) | CHRM5ADRA2CACHECHRM2CHRM4 | |
| SCHEMBL10722386 | 0.80 | CHRM5 (0.43) | CHRM5ADRA2CACHECHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975247-B2 | Methods and compositions of treating a flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNION UNIVERSITY (US) | 2015-03-10 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20110165164-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110052589-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20100247540-A1 | Methods and Compositions For Modulating Angiogenesis | CHEMOCENTRYX, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-7777009-B2 | Compositions for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. | 2009-02-26 | — | — | US | disclosed |
| US-7253007-B2 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165164-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CXCR3, CXCR2, ACKR3 | CHRM5 1928/4885ADRA2C 1177/4885ACHE 4558/4885 |
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CXCR3, CCR2, CCL2 | CHRM5 2019/4885ADRA2C 1550/4885ACHE 4428/4885 |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | CHRM5 571/4885ADRA2C 92/4885ACHE 1832/4885 |
| US-20110052589-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CXCR3, CXCR2, ACKR3 | CHRM5 1928/4885ADRA2C 1177/4885ACHE 4558/4885 |
| US-20100247540-A1 | Methods and Compositions For Modulating Angiogenesis | VEGFA, FLT4, PGF | CHRM5 3466/4885ADRA2C 2435/4885ACHE 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.