Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667979 | 0.82 | TSHR (0.57) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL10399614 | 0.78 | SRD5A2 (0.53) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL3170407 | 0.78 | CES2 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL10884184 | 0.78 | NPC1 (0.42) | NPC1RAB9AS1PR1S1PR3MAPT | |
| SCHEMBL3589190 | 0.77 | MAOA (0.41) | KCNQ3KCNQ2KCNE1KCNQ1RAPGEF3 | |
| SCHEMBL9693915 | 0.76 | KCNQ3 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL109599 | 0.76 | TSHR (0.65) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL30308290 | 0.76 | TSHR (0.65) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL20084007 | 0.76 | KCNQ3 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 | |
| SCHEMBL193605 | 0.76 | KCNQ3 (0.51) | KCNQ3KCNQ2KCNE1KCNQ1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | KCNQ3 4148/4885KCNQ2 4222/4885KCNE1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.