Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31410597 | 0.87 | KCNQ3 (0.42) | KCNQ3KCNQ2KCNE1KCNQ1CES2 | |
| SCHEMBL133027 | 0.84 | TSHR (0.52) | TSHR | |
| SCHEMBL11345564 | 0.84 | CES2 (0.59) | MAOAMAOBKCNQ3KCNQ2CES2 | |
| SCHEMBL29484265 | 0.84 | CES2 (0.59) | MAOAMAOBKCNQ3KCNQ2CES2 | |
| SCHEMBL30712974 | 0.84 | TSHR (0.52) | TSHR | |
| SCHEMBL12694460 | 0.81 | HSP90AA1 (0.49) | KCNH2TSHRSMN1; SMN2 | |
| SCHEMBL26690772 | 0.81 | P4HB (0.47) | CES2CES1 | |
| SCHEMBL7144096 | 0.79 | GSK3B (0.59) | MAOAMAOBKCNQ3KCNQ2KCNE1 | |
| SCHEMBL27503767 | 0.79 | KCNQ3 (0.44) | MAOAMAOBKCNQ3KCNQ2KCNE1 | |
| SCHEMBL138022 | 0.78 | GSK3B (0.57) | CES2CES1KCNH2TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063065-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LIMITED (GB) | 2010-03-11 | — | — | US | disclosed |
| EP-1937663-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036730-A9 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LTD (GB) | 2008-06-19 | — | — | WO | disclosed |
| WO-2007036730-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| US-20060046999-A1 | Monocyclic aroylpyridinones as antiinflammatory agents | BAYER HEALTHCARE AG (DE) | 2006-03-02 | — | — | US | disclosed |
| EP-1487794-A1 | MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS | Bayer Aktiengesellschaft (DE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003076405-A1 | MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS | BAYER HEALTHCARE AG (DE) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046999-A1 | Monocyclic aroylpyridinones as antiinflammatory agents | PTGIS, PTGES, PTGES2 | MAOA 543/4885MAOB 682/4885KCNQ3 3436/4885 |
| US-20100063065-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | PPARG, PPARD, PPARA | MAOA 4440/4885MAOB 3961/4885KCNQ3 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.