SCHEMBL9894640

SCHEMBL9894640

CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(CN)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSD17B10 Q99714 2/20 0.37
P2RX1 P51575 1/20 0.34
DHODH Q02127 1/20 0.34
TP53 P04637 1/20 0.34
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
ALOX15 P16050 2/20 0.33
KIT P10721 1/20 0.33
MAPT P10636 1/20 0.33
KLKB1 P03952 1/20 0.33
PLG P00747 2/20 0.33
KLK1 P06870 2/20 0.33
KLK6 Q92876 2/20 0.33
PTGER4 P35408 2/20 0.32
LOXL2 Q9Y4K0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1274909 0.85 KCNJ11 (0.38) HTTMEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL1274575 0.84 LOXL2 (0.44) HTTMEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL9895607 0.83 DHODH (0.34) HTTMEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL9895178 0.83 TRPA1 (0.38) HSD17B10TP53KDM4EALDH1A1HPGD
SCHEMBL1274926 0.82 MAPT (0.39) HSD17B10TP53KDM4EALDH1A1HPGD
SCHEMBL1274944 0.81 HDAC3 (0.40) MEN1KMT2ASMN1; SMN2HSD17B10KDM4E
SCHEMBL9895253 0.81 S1PR4 (0.39) HTTMEN1KMT2ASMN1; SMN2TP53
SCHEMBL1275950 0.81 KCNJ11 (0.36) HTTMEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL14850235 0.80 P2RX1 (0.46) MEN1KMT2ASMN1; SMN2P2RX1DHODH
SCHEMBL1275566 0.80 MAPT (0.41) MEN1KMT2AHSD17B10KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3153497-A2 PESTICIDAL CARBOXAMIDES Bayer Cropscience AG (DE) 2017-04-12 EP disclosed
US-9227923-B2 Pesticidal carboxamides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-01-05 US disclosed
US-20120149910-A1 Pesticidal Carboxamides BAYER CROPSCIENCE AG (DE) 2012-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149910-A1 Pesticidal Carboxamides DDT, ACHE, AADAC HTT 3709/4885MEN1 2546/4885KMT2A 183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.