Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.44 |
| ▸ | KDM5A | P29375 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | ADH5 | P11766 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9894845 | 0.92 | MAP4K4 (0.41) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL9895019 | 0.91 | MAP4K4 (0.53) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL9895487 | 0.89 | MAPK14 (0.43) | MAPK14CSNK1DMAP4K4MEN1ALDH1A1 | |
| SCHEMBL27933840 | 0.87 | KDM4C (0.42) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL9894907 | 0.86 | GABRA5 (0.44) | MAPK14CSNK1DMAP4K4TNIKPTGER4 | |
| SCHEMBL27933718 | 0.85 | MAPK1 (0.35) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL21416236 | 0.84 | ALDH1A1 (0.43) | MAPK14MEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL27933694 | 0.82 | KDM4C (0.55) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL9898195 | 0.82 | MAPK14 (0.37) | MAPK14CSNK1DKDM4CKDM5AKDM5B | |
| SCHEMBL9895619 | 0.82 | GABRA5 (0.47) | MAPK14MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649064-B1 | NOVEL TRIAZOLE COMPOUNDS III | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-2649064-A1 | NOVEL TRIAZOLE COMPOUNDS III | F. Hoffmann-La Roche AG (CH) | 2013-10-16 | — | — | EP | disclosed |
| CN-103249728-A | Novel triazole compounds III | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |
| US-8466181-B2 | 1,2,3-triazole-imidazole compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120149675-A1 | 1,2,3-TRIAZOLE-IMIDAZOLECOMPOUNDS | HOFFMANN-LA ROCHE INC. | 2012-06-14 | — | — | US | disclosed |
| WO-2012076590-A1 | NOVEL TRIAZOLE COMPOUNDS III | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149675-A1 | 1,2,3-TRIAZOLE-IMIDAZOLECOMPOUNDS | GABRA5, GABRA1, GABRB1 | MAPK14 4554/4885CSNK1D 805/4885KDM4C 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.