Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 13/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895927 | 1.00 | TACR1 (0.39) | TACR1KLK7JAK2JAK1HCRTR2 | |
| SCHEMBL2594354 | 0.77 | AGTR2 (0.40) | JAK2JAK1TRPM8 | |
| SCHEMBL22729197 | 0.77 | BCHE (0.39) | TACR1KLK7HCRTR2 | |
| SCHEMBL1426284 | 0.77 | OPRM1 (0.42) | TACR1KLK7TRPM8 | |
| SCHEMBL9896801 | 0.76 | AGTR2 (0.38) | HCRTR2 | |
| SCHEMBL9896800 | 0.76 | AGTR2 (0.38) | HCRTR2 | |
| SCHEMBL17506913 | 0.74 | ALDH1A1 (0.56) | — | |
| SCHEMBL3081890 | 0.74 | LIPG (0.43) | TRPM8 | |
| SCHEMBL2995001 | 0.74 | PDE4D (0.40) | HCRTR2 | |
| SCHEMBL2988770 | 0.74 | PDE4D (0.40) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | TACR1 3270/4885KLK7 3853/4885JAK2 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.