SCHEMBL9898679

SCHEMBL9898679

O=C1C=CC(=NO[Si](c2ccccc2)(c2ccccc2)c2ccccc2)c2c(Cl)c(Cl)c(Cl)c(Cl)c21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 2/20 0.33
S1PR2 O95136 1/20 0.33
PKM P14618 1/20 0.33
XBP1 P17861 1/20 0.33
MPI P34949 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MEN1 O00255 1/20 0.30
USP2 O75604 1/20 0.30
TP53 P04637 1/20 0.30
GLA P06280 1/20 0.30
CYP3A4 P08684 1/20 0.30
THRB P10828 1/20 0.30
HPGD P15428 1/20 0.30
ALOX15 P16050 1/20 0.30
ALOX12 P18054 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2049537 0.91
SCHEMBL9898050 0.80 MEN1 (0.34) ALDH1A1LMNAMAPTMEN1USP2
SCHEMBL9898820 0.74 MAPT (0.62) ALDH1A1LMNAMAPTS1PR2PKM
SCHEMBL9899204 0.74 MAOA (0.41) ALDH1A1LMNAMAPTS1PR2PKM
SCHEMBL9898417 0.72 DUT (0.31)
SCHEMBL9899473 0.72 ALDH1A1 (0.38) ALDH1A1LMNAMAPTS1PR2PKM
SCHEMBL2045377 0.69
SCHEMBL2048693 0.69
SCHEMBL9899257 0.67 MAPT (0.37) ALDH1A1LMNAMAPTHTTNPSR1
SCHEMBL9902097 0.66 ALDH1A1 (0.60) ALDH1A1LMNAMAPTMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748531-B2 Polymers functionalized with oxime compounds containing an acyl group BRIDGESTONE CORPORATION (JP) 2014-06-10 US claimed
US-20120149833-A1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORPORATION (JP) 2012-06-14 US claimed
EP-2649102-B1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORP (JP) 2014-11-26 EP disclosed
US-8748531-B2 Polymers functionalized with oxime compounds containing an acyl group BRIDGESTONE CORPORATION (JP) 2014-06-10 US disclosed
US-20120149833-A1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORPORATION (JP) 2012-06-14 US disclosed