Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815614 | 0.85 | KDM4E (0.38) | RECQLBTKHDAC8 | |
| SCHEMBL764017 | 0.80 | RECQL (0.52) | RECQLPRKCIPLAUMAOADYRK1A | |
| SCHEMBL29935916 | 0.80 | RECQL (0.52) | RECQLPRKCIPLAUMAOADYRK1A | |
| SCHEMBL1972140 | 0.80 | NOS3 (0.52) | RECQLBTKHDAC8CYP3A4CYP2D6 | |
| SCHEMBL20920751 | 0.77 | BTK (0.36) | BTKHDAC8CYP3A4LOXL2NOS3 | |
| SCHEMBL20586694 | 0.77 | BTK (0.44) | BTKGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL19728333 | 0.76 | GABRA1 (0.37) | BTKHDAC8GABRA1GABRB2NOS3 | |
| SCHEMBL20391850 | 0.74 | ACHE (0.39) | RECQL | |
| SCHEMBL24696617 | 0.73 | TDP1 (0.41) | CYP3A4 | |
| SCHEMBL11456043 | 0.73 | CA12 (0.36) | RECQLPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649076-B1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649076-B1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8933015-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140023616-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2014-01-23 | — | — | US | disclosed |
| US-20140023616-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2014-01-23 | — | — | US | disclosed |
| US-20140023616-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2014-01-23 | — | — | US | disclosed |
| EP-2649076-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8513184-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513184-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513184-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20130022573-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130022573-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130022573-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | SELCIA LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| WO-2012078915-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012078915-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140023616-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, ZC3HAV1, CYP2F1 | RECQL 1113/4885BTK 2251/4885PRKCI 2850/4885 |
| US-20130022573-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, ZC3HAV1, CYP2F1 | RECQL 1113/4885BTK 2251/4885PRKCI 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.