Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.39 |
| ▸ | ACACB | O00763 | 4/20 | 0.37 |
| ▸ | ACACA | Q13085 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9939952 | 0.97 | PTGES (0.40) | PTGESOPRL1ACACBACACAROCK2 | |
| SCHEMBL9939951 | 0.89 | PTGES (0.46) | PTGES | |
| SCHEMBL9899766 | 0.84 | PTGES (0.35) | PTGESOPRL1OPRM1OPRK1 | |
| SCHEMBL9940007 | 0.83 | ROCK2 (0.39) | PTGESOPRL1ROCK2OPRK1 | |
| SCHEMBL9939955 | 0.81 | PTGES (0.33) | PTGESOPRK1 | |
| SCHEMBL9899436 | 0.80 | OPRL1 (0.39) | PTGESOPRL1ROCK2 | |
| SCHEMBL9939926 | 0.78 | PTGES (0.49) | PTGES | |
| SCHEMBL9940077 | 0.76 | PTGES (0.46) | PTGES | |
| SCHEMBL9899918 | 0.75 | OPRK1 (0.40) | PTGESOPRK1 | |
| SCHEMBL9940008 | 0.75 | PTGES (0.42) | PTGESOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649052-A1 | 2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION | Boehringer Ingelheim International GmbH (DE) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076672-A1 | 2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |