Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899816 | 0.78 | SLC6A4 (0.42) | HTR2AHRH1SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL4575392 | 0.75 | HRH1 (0.60) | HTR2AHRH1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9899776 | 0.73 | IDO1 (0.42) | HTR2AHRH1SLC6A4ALDH1A1LMNA | |
| SCHEMBL9899903 | 0.72 | HTR2A (0.37) | HTR2AHRH1SLC6A4ALDH1A1LMNA | |
| SCHEMBL5410942 | 0.69 | HRH1 (0.58) | HTR2AHRH1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9915910 | 0.69 | LTB4R (0.53) | SLC6A3TRPA1LTB4R | |
| SCHEMBL5412370 | 0.68 | HRH1 (0.56) | HTR2AHRH1TRPA1SIGMAR1KDM1A | |
| SCHEMBL1667104 | 0.68 | CTSA (0.48) | — | |
| SCHEMBL1884939 | 0.67 | LMNA (0.59) | HTR2AHRH1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9899391 | 0.67 | TBXAS1 (0.42) | HTR2AHRH1SLC6A4SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |