Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303849 | 0.85 | GLP1R (0.67) | GLP1RKDRGAAICAM1SELE | |
| SCHEMBL6304106 | 0.80 | GLP1R (0.58) | GLP1RKDRGAAICAM1SELE | |
| SCHEMBL6303827 | 0.75 | NPC1 (0.46) | GLP1RKDRGAANPC1RAB9A | |
| SCHEMBL6306350 | 0.74 | GLP1R (0.41) | GLP1RGAANPC1RAB9APOLB | |
| SCHEMBL6306346 | 0.73 | GLP1R (0.40) | GLP1RKDRPOLBMAPTNPSR1 | |
| SCHEMBL9905747 | 0.69 | KDM4E (0.40) | GLP1RNPC1RAB9AHSD17B10NPSR1 | |
| SCHEMBL9925831 | 0.67 | GLP1R (0.34) | GLP1RNPC1RAB9AMAPTNPSR1 | |
| SCHEMBL9900753 | 0.65 | ALDH1A1 (0.46) | GAANPC1RAB9APOLBHSD17B10 | |
| SCHEMBL8043918 | 0.65 | MAPT (0.45) | GAAICAM1SELEVCAM1POLB | |
| SCHEMBL9900886 | 0.62 | GLP1R (0.35) | GLP1RGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |