Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307235 | 0.81 | PIK3R1 (0.33) | PIK3R1PIK3CAPOLBHPGDALDH1A1 | |
| SCHEMBL6306350 | 0.77 | GLP1R (0.41) | GLP1RPOLBMAPTKDM4EHPGD | |
| SCHEMBL6303849 | 0.74 | GLP1R (0.67) | GLP1RPOLBMAPTKDM4EALDH1A1 | |
| SCHEMBL6303827 | 0.73 | NPC1 (0.46) | GLP1RPIK3CAMAPTKDM4EHPGD | |
| SCHEMBL6304414 | 0.73 | PIK3R1 (0.39) | PIK3R1PIK3CAPOLBMAPTTRPA1 | |
| SCHEMBL6303978 | 0.73 | PIK3R1 (0.39) | PIK3R1PIK3CAPOLBMAPTTRPA1 | |
| SCHEMBL9900107 | 0.73 | GLP1R (0.48) | GLP1RPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL6304106 | 0.70 | GLP1R (0.58) | GLP1RMAPTALDH1A1KDR | |
| SCHEMBL1954351 | 0.62 | ALDH1A1 (0.42) | MAPTXDHKDM4EHPGDALDH1A1 | |
| SCHEMBL6310836 | 0.62 | ALDH1A1 (0.44) | POLBMAPTNPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927214-B1 | Non-peptide GLP-1 agonists | NOVO NORDISK A/S (DK) | 2005-08-09 | — | — | US | disclosed |