Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.40 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990623 | 0.87 | NOS3 (0.51) | NOS3NOS1CHEK1CYP11B2NPC1 | |
| SCHEMBL20424980 | 0.86 | HDAC8 (0.45) | CYP11B2AOC3 | |
| SCHEMBL990712 | 0.81 | NOS3 (0.44) | NOS3NOS1CHEK1CYP11B2NPC1 | |
| SCHEMBL19087150 | 0.80 | NOS3 (0.54) | NOS3NOS1CHEK1CYP11B2 | |
| SCHEMBL989973 | 0.78 | NPC1 (0.41) | NOS3NOS1CHEK1CYP11B2NPC1 | |
| SCHEMBL20425007 | 0.78 | ITGB3 (0.64) | NPC1RAB9AITGB3ITGA2BPLOD2 | |
| SCHEMBL28739636 | 0.77 | ITGB3 (0.62) | NPC1RAB9AITGB3ITGA2BPLOD2 | |
| SCHEMBL2371447 | 0.76 | ITGB3 (0.63) | NPC1RAB9AITGB3ITGA2B | |
| SCHEMBL23432683 | 0.75 | NOS3 (0.50) | NOS3NOS1CHEK1CYP11B2 | |
| SCHEMBL27767066 | 0.74 | HDAC3 (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270001-A1 | Indolylmaleimide derivatives as PKC inhibitors | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| CN-101933926-A | Indolylmaleimde derivatives as PKC inhibitors | NOVARTIS AG | 2011-01-05 | — | — | CN | disclosed |
| CN-1910173-B | Indolylmaleimide derivatives as PKC inhibitors | NOVARTIS AG | 2010-06-09 | — | — | CN | disclosed |
| CN-1910173-A | Indolylmaleimide derivatives as PKC inhibitors | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |