Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.36 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.36 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.36 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990018 | 0.81 | NOS3 (0.49) | NOS3NOS1CYP11B2CHEK1AOC3 | |
| SCHEMBL990623 | 0.80 | NOS3 (0.51) | NOS3NOS1CYP11B2CHEK1AOC3 | |
| SCHEMBL20425006 | 0.76 | TGFBR1 (0.44) | CYP11B2AOC3TGFBR1ACVR1RAB9A | |
| SCHEMBL22944700 | 0.74 | GPR119 (0.51) | GPR119 | |
| SCHEMBL990733 | 0.74 | WNT1 (0.46) | AOC3GPR119 | |
| SCHEMBL19087150 | 0.73 | NOS3 (0.54) | NOS3NOS1CYP11B2CHEK1AGXT | |
| SCHEMBL990624 | 0.73 | HCAR2 (0.39) | CYP11B2 | |
| SCHEMBL17999509 | 0.73 | MTNR1A (0.42) | CYP11B2 | |
| SCHEMBL12205269 | 0.72 | GPR119 (0.56) | GPR119 | |
| SCHEMBL20424980 | 0.71 | HDAC8 (0.45) | CYP11B2AOC3TGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270001-A1 | Indolylmaleimide derivatives as PKC inhibitors | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |