Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370639 | 0.84 | CA1 (0.39) | LMNAMAPTSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL12853879 | 0.76 | CA1 (0.56) | LMNAMAPTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL10640071 | 0.72 | TP53 (0.52) | LMNAMAPTJAK2GAASMN1; SMN2 | |
| SCHEMBL12853863 | 0.72 | KMT2A (0.41) | LMNAMAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL9901000 | 0.72 | SMN1; SMN2 (0.42) | LMNAMAPTJAK2GAASMN1; SMN2 | |
| SCHEMBL4648915 | 0.71 | CA12 (0.62) | LMNASMN1; SMN2L3MBTL1POLBMTNR1A | |
| SCHEMBL11837900 | 0.71 | ALDH1A1 (0.56) | MAPTGAAL3MBTL1GLAKDM4E | |
| SCHEMBL9900020 | 0.68 | APP (0.39) | LMNAMAPTJAK2GAASMN1; SMN2 | |
| SCHEMBL9157736 | 0.68 | ALDH1A1 (0.39) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7795831 | 0.68 | TDP1 (0.42) | LMNAMAPTGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |