Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.48 |
| ▸ | DAO | P14920 | 3/20 | 0.42 |
| ▸ | DDO | Q99489 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL269768 | 0.76 | KDM4E (0.48) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29547 | 0.74 | AHR (0.37) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11785225 | 0.69 | ALDH1A1 (0.38) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6185593 | 0.68 | PTGS2 (0.35) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL239920 | 0.67 | KDM4E (1.00) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29495630 | 0.67 | KDM4E (1.00) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6048372 | 0.67 | ACHE (0.39) | ALDH1A1CYP1A2LMNA | |
| SCHEMBL10813818 | 0.67 | ALDH1A1 (0.32) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL67229 | 0.67 | KIF11 (0.36) | BRD4KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3860446 | 0.67 | PBRM1 (0.38) | BRD4KDM4EGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | claimed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |