Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012686 | 0.76 | HSPA5 (0.50) | CA2LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL2116651 | 0.76 | AKR1B1 (0.42) | LMNAALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL2116652 | 0.76 | AKR1B1 (0.42) | LMNAALDH1A1HPGDHSD17B10RAB9A | |
| Catechol SCHEMBL10950941 | 0.74 | MAOB (0.50) | CA2LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL9901526 | 0.74 | PTPN1 (0.45) | ALDH1A1HPGDRECQLKDM4EPOLB | |
| SCHEMBL3753802 | 0.72 | AKR1B1 (0.37) | CA2ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL69556 | 0.71 | GABRA1 (0.48) | CA2LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL2727597 | 0.71 | ERN1 (0.43) | CA2LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL9900604 | 0.70 | THRB (0.37) | CA2LMNAALDH1A1HPGDTDP1 | |
| SCHEMBL12466481 | 0.69 | GAA (0.51) | ALDH1A1TDP1KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |