Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | SELL | P14151 | 1/20 | 0.41 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | SELE | P16581 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900768 | 0.74 | CA2 (0.36) | TRPA1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL9901006 | 0.74 | PTPN1 (0.47) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL29115719 | 0.74 | PTPN1 (0.47) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL9900406 | 0.73 | PTPN1 (0.41) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL9788451 | 0.72 | PTPN1 (0.69) | PTPN1BACE1TRPA1CYP19A1MAOA | |
| SCHEMBL8999712 | 0.69 | SELL (0.55) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL21180310 | 0.68 | PTPN1 (0.63) | PTPN1BACE1TRPA1CYP19A1MAOA | |
| SCHEMBL3182711 | 0.67 | SELL (0.52) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL9579926 | 0.67 | SELL (0.52) | PTPN1BACE1SELLSELPSELE | |
| SCHEMBL8376741 | 0.67 | SELL (0.46) | PTPN1BACE1SELLSELPSELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |