Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1117837 | 0.82 | CTSB (0.36) | SMN1; SMN2PPIAMAPT | |
| SCHEMBL5532804 | 0.81 | HDAC1 (0.43) | HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9901321 | 0.81 | SMN1; SMN2 (0.35) | LMNAMEN1KMT2ASMN1; SMN2PPIA | |
| SCHEMBL9900673 | 0.80 | P2RX7 (0.34) | LMNAKDM4EHTTPKMP2RX7 | |
| SCHEMBL1117763 | 0.79 | ADORA2A (0.36) | PPIA | |
| SCHEMBL14119267 | 0.78 | RNASEH1 (0.40) | LMNAP2RX7ELANECA1CA2 | |
| SCHEMBL14212555 | 0.78 | LMNA (0.34) | LMNAKDM4EP2RX7ELANECA1 | |
| SCHEMBL14212557 | 0.77 | P2RX7 (0.35) | LMNAKDM4EHTTPKMP2RX7 | |
| SCHEMBL1117832 | 0.75 | ADORA2A (0.35) | ELANEPPIA | |
| SCHEMBL9942946 | 0.73 | CA1 (0.33) | LMNAP2RX7ELANECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649077-A1 | HIV INTEGRASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078834-A1 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-06-14 | — | — | WO | disclosed |