Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900752 | 0.81 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL9905731 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL31448066 | 0.68 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL11089170 | 0.68 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL24173764 | 0.67 | DYRK1A (0.36) | ALDH1A1SMN1; SMN2MAPTPOLBMEN1 | |
| SCHEMBL17865520 | 0.66 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL19829397 | 0.65 | ALDH1A1 (0.95) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL6690095 | 0.64 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL22874622 | 0.64 | TEAD4 (0.57) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 | |
| SCHEMBL554766 | 0.64 | TEAD4 (0.57) | ALDH1A1SMN1; SMN2TEAD4MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |