Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.34 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.34 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.34 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106587 | 0.87 | PLAAT3 (0.33) | PLAAT3PLAAT5PLAAT2PLAAT4SCN9A | |
| SCHEMBL9900795 | 0.83 | PLA2G7 (0.48) | PLA2G7 | |
| SCHEMBL9892569 | 0.80 | CNR2 (0.37) | IDH1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL9106957 | 0.79 | PLA2G7 (0.34) | PLAAT3PLAAT5PLAAT2PLAAT4SCN9A | |
| SCHEMBL9889709 | 0.76 | CYP2C9 (0.35) | SCN9AHPGDXDHSMN1; SMN2NPC1 | |
| SCHEMBL9105140 | 0.72 | PLAAT3 (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4SCN9A | |
| SCHEMBL9105550 | 0.72 | L3MBTL1 (0.46) | SCN9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL876438 | 0.72 | L3MBTL1 (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4SCN9A | |
| SCHEMBL9107066 | 0.72 | CNR2 (0.39) | IDH1SCN9ASMN1; SMN2RAF1NPC1 | |
| SCHEMBL9900797 | 0.71 | MEN1 (0.39) | SCN9APLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |