Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | JAK3 | P52333 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790967 | 0.76 | CHRNB2 (0.52) | DPP4JAK2JAK1JAK3TYK2 | |
| SCHEMBL22735781 | 0.74 | JAK2 (0.45) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL16665410 | 0.73 | JAK2 (0.34) | DPP4JAK2JAK1JAK3TYK2 | |
| SCHEMBL9901341 | 0.73 | DPP4 (0.50) | DPP4HCRTR2 | |
| SCHEMBL25320081 | 0.73 | CYP3A4 (0.46) | DPP4LMNACCR1KCNH2CYP3A4 | |
| SCHEMBL15458220 | 0.73 | CYP3A4 (0.46) | DPP4LMNACCR1KCNH2CYP3A4 | |
| SCHEMBL2455912 | 0.73 | DPP4 (0.47) | DPP4JAK2JAK1JAK3HCRTR2 | |
| SCHEMBL28132789 | 0.73 | DPP4 (0.47) | DPP4JAK2JAK1JAK3HCRTR2 | |
| SCHEMBL12632401 | 0.73 | CYP3A4 (0.46) | DPP4LMNACCR1KCNH2CYP3A4 | |
| SCHEMBL24568323 | 0.72 | DPP4 (0.36) | DPP4JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |