Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.45 |
| ▸ | JAK1 | P23458 | 19/20 | 0.45 |
| ▸ | JAK3 | P52333 | 19/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491119 | 0.80 | CTSK (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL2378971 | 0.80 | CTSK (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL14790967 | 0.78 | CHRNB2 (0.52) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL11380507 | 0.77 | PREP (0.47) | PREPFAP | |
| SCHEMBL2455912 | 0.75 | DPP4 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL28132789 | 0.75 | DPP4 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL9902299 | 0.74 | DPP4 (0.38) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19249275 | 0.74 | DPP4 (0.46) | JAK2JAK1JAK3PREP | |
| Hydrochloric Acid SCHEMBL14737849 | 0.74 | DPP4 (0.46) | JAK2JAK1JAK3 | |
| SCHEMBL16665410 | 0.72 | JAK2 (0.34) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |