Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902743 | 0.89 | HTR6 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL4690981 | 0.88 | HTR6 (0.61) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL9903357 | 0.87 | HTR6 (0.59) | HTR6HTR7DRD2HTR2AHTR2B | |
| SCHEMBL9903063 | 0.86 | HTR6 (0.43) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL9903634 | 0.84 | HTR6 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL3136898 | 0.81 | HTR6 (0.60) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL4702293 | 0.81 | CHRNB2 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL9903675 | 0.79 | HTR6 (0.47) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL9903853 | 0.77 | HTR6 (0.60) | HTR6HTR7DRD2HTR2AHTR2B | |
| SCHEMBL9903510 | 0.77 | HTR6 (0.60) | HTR6HTR7DRD2HTR2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |