Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.62 |
| ▸ | HTR7 | P34969 | 5/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903510 | 0.88 | HTR6 (0.60) | HTR6HTR7HTR3AHTR2BDRD2 | |
| SCHEMBL9903167 | 0.88 | HTR6 (0.58) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL9902745 | 0.87 | HTR6 (0.66) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL9903357 | 0.82 | HTR6 (0.59) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL9903819 | 0.82 | HTR6 (0.45) | HTR6HTR7HTR2AHTR2BDRD2 | |
| SCHEMBL9903853 | 0.81 | HTR6 (0.60) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL9901916 | 0.80 | HTR3A (0.51) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL5068818 | 0.80 | HTR6 (0.77) | HTR6HTR7HTR2AHTR2BDRD2 | |
| SCHEMBL9903412 | 0.79 | HTR6 (0.60) | HTR6HTR7HTR2AHTR3AHTR2B | |
| SCHEMBL9902699 | 0.77 | HTR3A (0.48) | HTR6HTR7HTR3AHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |