Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903357 | 0.89 | HTR6 (0.59) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9903510 | 0.88 | HTR6 (0.60) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9903853 | 0.88 | HTR6 (0.60) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9902745 | 0.88 | HTR6 (0.66) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9903672 | 0.88 | HTR6 (0.62) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9903233 | 0.87 | CHRM2 (0.48) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9903406 | 0.87 | THRB (0.54) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL9901916 | 0.86 | HTR3A (0.51) | HTR6DRD2HTR7HTR2BHTR2C | |
| SCHEMBL4690981 | 0.86 | HTR6 (0.61) | HTR6DRD2HTR7HTR2BHTR3A | |
| SCHEMBL9903412 | 0.85 | HTR6 (0.60) | HTR6DRD2HTR7HTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |