Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EEF2 | P13639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9943564 | 0.80 | PDE4A (0.35) | ADORA2AADORA2BMEN1KMT2A | |
| SCHEMBL28144480 | 0.77 | EEF2K (0.38) | EEF2KADORA2AADORA2BEEF2 | |
| SCHEMBL9904241 | 0.77 | ALDH1A1 (0.44) | MEN1KMT2A | |
| SCHEMBL9904076 | 0.73 | ADORA2B (0.37) | ADORA2AADORA2BMEN1KMT2A | |
| SCHEMBL9943417 | 0.67 | EPHX2 (0.35) | MEN1KMT2A | |
| SCHEMBL2536394 | 0.66 | MAPT (0.35) | KMT2A | |
| SCHEMBL7269080 | 0.64 | CNR2 (0.39) | ADORA2AADORA2BMEN1KMT2A | |
| SCHEMBL28528919 | 0.64 | HDAC1 (0.36) | MEN1KMT2A | |
| SCHEMBL28634835 | 0.64 | MCHR1 (0.45) | MEN1KMT2A | |
| SCHEMBL10858163 | 0.63 | ALDH1A1 (0.43) | ADORA2AADORA2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465859-A1 | 8-Triazolylxanthine derivatives, processes for their production and their use as adenosine receptor antagonists | Life & Brain GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| WO-2012076974-A1 | 8-TRIAZOLYLXANTHINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS | LIFE & BRAIN GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |