Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912672 | 0.78 | KMT2A (0.43) | OPRM1OPRD1CNR1CNR2KMT2A | |
| SCHEMBL2088247 | 0.78 | MAPT (0.46) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL9900566 | 0.78 | OPRM1 (0.44) | GAAKDM4EOPRM1OPRD1OPRK1 | |
| SCHEMBL7484764 | 0.78 | LMNA (0.56) | GAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7395753 | 0.78 | OPRM1 (0.46) | GAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3108615 | 0.78 | KMT2A (0.40) | GAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7653400 | 0.76 | OPRM1 (0.39) | GAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6926382 | 0.75 | KDM4E (0.49) | GAAKDM4EKMT2ACHRM4CHRM5 | |
| SCHEMBL1104991 | 0.73 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1CNR1 | |
| SCHEMBL1221639 | 0.73 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm S.p.A. (IT) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |