Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | ODC1 | P11926 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SPTLC1 | O15269 | 1/20 | 0.32 |
| ▸ | SPTLC2 | O15270 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004419 | 0.78 | ARG1 (0.51) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL1915583 | 0.75 | ARG1 (0.32) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL19458872 | 0.71 | TSHR (0.31) | SMN1; SMN2 | |
| SCHEMBL1916171 | 0.69 | TSHR (0.33) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL28500369 | 0.69 | ODC1 (0.35) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL27734538 | 0.68 | ALDH1A1 (0.59) | ARG1ARG2ODC1MEN1ALDH1A1 | |
| SCHEMBL20876015 | 0.68 | — | — | |
| SCHEMBL28095353 | 0.67 | GGT1 (0.52) | ARG1ARG2KDM4EMAPTBLM | |
| SCHEMBL19458870 | 0.67 | — | — | |
| SCHEMBL30206860 | 0.67 | ALDH1A1 (0.42) | ARG1ARG2ODC1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648735-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | The University Of British Columbia (CA) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076985-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-06-14 | — | — | WO | disclosed |