Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906238 | 0.91 | KMT2A (0.45) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL13495590 | 0.86 | KMT2A (0.48) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL9906249 | 0.81 | HTR1A (0.42) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL9906235 | 0.74 | KMT2A (0.38) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL9906233 | 0.71 | HSD17B10 (0.42) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL13143684 | 0.70 | KMT2A (0.54) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL13142892 | 0.70 | KMT2A (0.54) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL13143681 | 0.70 | KMT2A (0.54) | KMT2ATARDBPHTR1ADRD2HSD17B10 | |
| SCHEMBL24601915 | 0.70 | HSD17B10 (0.60) | KMT2ATARDBPHSD17B10CYP2C9MEN1 | |
| SCHEMBL15339490 | 0.69 | HSD17B10 (0.51) | KMT2ATARDBPHTR1ADRD2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130157986-A1 | NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE | INVASC THERAPEUTICS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-8198317-B2 | Methylenedioxy phenolic compounds and their use to treat disease | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100035849-A1 | NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE | OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035849-A1 | NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE | REN, PCSK9, ALOX12 | KMT2A 1399/4885TARDBP 2677/4885HTR1A 1391/4885 |
| US-20130157986-A1 | NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE | REN, PCSK9, COMT | KMT2A 1673/4885TARDBP 2670/4885HTR1A 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.