Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 10/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 9/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 9/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.39 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744681 | 0.85 | CHRNA7 (0.46) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL746349 | 0.84 | CHRNA7 (0.45) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2484828 | 0.69 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2484827 | 0.69 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL744341 | 0.69 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL31317869 | 0.69 | CYP11B1 (0.63) | PIP4K2APIP4K2BPRKCQ | |
| Hydrochloric Acid SCHEMBL2484675 | 0.68 | FYN (0.47) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL744366 | 0.68 | CHRNA7 (0.53) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1177376 | 0.67 | SLC6A2 (0.54) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1177375 | 0.67 | SLC6A2 (0.54) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872017-B2 | Fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBVIE INC. | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | MALT1, BMP2, ALKBH2 | CHRNA7 2776/4885KCNH2 708/4885CHRNB2 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.