Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120384 | 0.88 | GAA (0.49) | GAARAB9ACNR1MEN1LMNA | |
| Hydrochloric Acid SCHEMBL119951 | 0.87 | GAA (0.48) | GAARAB9ACNR1MEN1LMNA | |
| SCHEMBL989796 | 0.81 | TAAR1 (0.55) | NPC1RAB9ATAAR1CNR1MEN1 | |
| SCHEMBL934513 | 0.79 | GAA (0.46) | GAARAB9ACNR1MEN1LMNA | |
| SCHEMBL3664015 | 0.79 | MAPT (0.43) | GAARAB9AMEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL3664723 | 0.78 | MAPT (0.42) | GAARAB9AMEN1LMNAKMT2A | |
| SCHEMBL989861 | 0.73 | CNR1 (0.57) | GAARAB9ATAAR1CNR1MEN1 | |
| SCHEMBL990628 | 0.73 | CNR1 (0.57) | GAARAB9ATAAR1CNR1MEN1 | |
| SCHEMBL12140714 | 0.72 | GAA (0.58) | GAATAAR1MEN1LMNAKMT2A | |
| SCHEMBL575038 | 0.72 | GAA (0.59) | GAANPC1RAB9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102480955-A | Pyrido [4,3-b ] indoles and methods of use | MEDIVATION TECHNOLOGIES INC | 2012-05-30 | — | — | CN | disclosed |
| EP-2274307-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009120720-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES,INC. (US) | 2009-10-01 | — | — | WO | disclosed |