Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.43 |
| ▸ | HTR5A | P47898 | 3/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108194 | 0.88 | HTR5A (0.48) | CSNK2A2CSNK2BHTR5AP4HA1IP6K1 | |
| SCHEMBL9907348 | 0.86 | MAPKAPK2 (0.44) | CSNK2A2CSNK2BHTR5APLAUKDM4E | |
| SCHEMBL9907472 | 0.85 | HTR5A (0.44) | HTR5AIP6K1IP6K3IP6K2PLAU | |
| Formaldehyde SCHEMBL9108251 | 0.85 | HTR5A (0.46) | CSNK2A2CSNK2BHTR5AP4HA1IP6K1 | |
| SCHEMBL9907457 | 0.85 | HTT (0.47) | KDM4EKDM6BMAPTKDM5CKDM4C | |
| SCHEMBL9907834 | 0.83 | HTR5A (0.61) | HTR5A | |
| SCHEMBL9907351 | 0.82 | HTR5A (0.42) | CSNK2A2CSNK2BHTR5AKDM4AALDH1A1 | |
| SCHEMBL9909165 | 0.82 | LMNA (0.49) | HTR5AKDM4EKDM6BMAPTKDM5A | |
| SCHEMBL9907387 | 0.81 | MAPKAPK2 (0.45) | CSNK2A2CSNK2BIP6K1IP6K3IP6K2 | |
| SCHEMBL9907344 | 0.80 | HTR5A (0.43) | CSNK2A2CSNK2BHTR5AMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | CSNK2A2 4132/4885CSNK2B 4303/4885HTR5A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.