Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108194 | 0.89 | HTR5A (0.48) | HTR5AIP6K1IP6K3IP6K2PTGDR2 | |
| SCHEMBL9907348 | 0.88 | MAPKAPK2 (0.44) | HTR5APTGDR2POLBMEN1NPC1 | |
| Formaldehyde SCHEMBL9108251 | 0.87 | HTR5A (0.46) | HTR5AIP6K1IP6K3IP6K2PTGDR2 | |
| SCHEMBL9909165 | 0.86 | LMNA (0.49) | HTR5APTGDR2NPC1RAB9ATGFBR1 | |
| SCHEMBL9907469 | 0.86 | TGFBR1 (0.48) | HTR5APTGDR2MEN1KMT2ATDP1 | |
| SCHEMBL9907403 | 0.86 | JAK2 (0.45) | IP6K1IP6K3IP6K2PTGDR2POLB | |
| SCHEMBL9907462 | 0.85 | CSNK2A2 (0.43) | HTR5AIP6K1IP6K3IP6K2PTGDR2 | |
| SCHEMBL9907840 | 0.83 | HTR5A (0.63) | HTR5APLAU | |
| SCHEMBL9907351 | 0.81 | HTR5A (0.42) | HTR5APOLBTGFBR1GAKRIPK2 | |
| SCHEMBL9907471 | 0.81 | PTGDR2 (0.43) | HTR5APTGDR2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885IP6K1 4169/4885IP6K3 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.