Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990673 | 0.86 | AKT1 (0.42) | SMOMEN1KMT2AMAPK10HRH4 | |
| SCHEMBL989945 | 0.83 | HTR3A (0.43) | SMOHTR3ARAB9AL3MBTL1 | |
| SCHEMBL990764 | 0.82 | MAPT (0.45) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL27658356 | 0.79 | SMO (0.40) | SMOMEN1KMT2AMAPK10USP2 | |
| SCHEMBL27678426 | 0.75 | HTR3A (0.48) | HRH4HTR3A | |
| SCHEMBL990479 | 0.74 | SMO (0.43) | SMOMEN1KMT2AMAPK10USP2 | |
| SCHEMBL989988 | 0.74 | HTR3A (0.39) | SMOHRH4HTR3ARAB9AL3MBTL1 | |
| SCHEMBL14558281 | 0.71 | WNT1 (0.49) | SMOMEN1KMT2AHRH4USP2 | |
| SCHEMBL16829614 | 0.71 | L3MBTL1 (0.48) | MEN1KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL992615 | 0.71 | HTR3A (0.43) | SMOHRH4HTR3ARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270001-A1 | Indolylmaleimide derivatives as PKC inhibitors | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |