Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL2231852 | 0.90 | LDHA (0.38) | CYP2C19 | |
| Metformin SCHEMBL2815239 | 0.88 | LDHA (0.36) | CYP2C19 | |
| Metformin SCHEMBL7647374 | 0.88 | PHF8 (0.41) | FFAR3CYP2C19 | |
| Metformin SCHEMBL1558869 | 0.88 | PHF8 (0.41) | FFAR3CYP2C19 | |
| Metformin SCHEMBL1557197 | 0.88 | GLRA1 (0.40) | CYP2C19 | |
| Metformin SCHEMBL991940 | 0.87 | FFAR3 (0.46) | FFAR3 | |
| Metformin SCHEMBL7123890 | 0.86 | PHF8 (0.39) | — | |
| Metformin SCHEMBL4410446 | 0.85 | CRBN (0.33) | FFAR3 | |
| Metformin SCHEMBL4364474 | 0.85 | LMNA (0.30) | — | |
| Metformin SCHEMBL1323029 | 0.85 | CRBN (0.33) | FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008053-A3 | PROPIONATE OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME | 한올바이오파마주식회사 (KR) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011008053-A2 | PROPIONATE OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME | 한올바이오파마주식회사 (KR) | 2011-01-20 | — | — | WO | disclosed |