Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.61 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912204 | 0.83 | PTGDR (0.56) | BRAFPTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL9912237 | 0.82 | PTGDR (0.52) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL9912205 | 0.81 | PTGDR (0.52) | BRAFPTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL4495486 | 0.80 | PTGDR (0.80) | PTGDR | |
| SCHEMBL13894999 | 0.79 | ALDH1A1 (0.47) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL13895137 | 0.79 | PTGDR (0.64) | PTGDRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9912189 | 0.78 | BCHE (0.47) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL9912276 | 0.77 | PTGDR (0.63) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL9912250 | 0.76 | PTGDR (0.85) | PTGDR | |
| SCHEMBL4497663 | 0.76 | PTGDR (0.68) | BRAFPTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193183-B2 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2012-06-05 | — | — | US | disclosed |