SCHEMBL9912694

SCHEMBL9912694

Cc1cc(CN(c2ccc(Nc3ccc(CC(C)CC(C)(C)C)cc3)cc2)C(C)CC(C)C)c(O)c(C(C)(C)C)c1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 1/20 0.36
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
HIF1A Q16665 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP2D6 P10635 2/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2741276 0.91 CYP1A2 (0.32) CYP2C19HIF1ACYP2D6CYP1A2
SCHEMBL2812384 0.91 CYP1A2 (0.32) CYP2C19HIF1ACYP2D6CYP1A2
SCHEMBL12875832 0.91 CYP1A2 (0.32) CYP2C19HIF1ACYP2D6CYP1A2
SCHEMBL12890010 0.89
SCHEMBL14963226 0.89 CYP1A2 (0.30) HIF1ACYP2D6CYP1A2
SCHEMBL14468734 0.88 CYP1A2 (0.30) CYP2D6CYP1A2
SCHEMBL2741272 0.88 ALDH1A1 (0.36) SMN1; SMN2
SCHEMBL2785231 0.88 ALDH1A1 (0.36) SMN1; SMN2
SCHEMBL2788691 0.88 ALDH1A1 (0.36) SMN1; SMN2
SCHEMBL2788435 0.86 ALDH1A1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9523060-B2 Lubricant oil compositions POLNOX CORPORATION (US) 2016-12-20 US disclosed
US-9388120-B2 Nitrogen and hindered phenol containing dual functional macromolecular antioxidants: synthesis, performances and applications POLNOX CORPORATION (US) 2016-07-12 US disclosed
US-20150159109-A1 Lubricant Oil Compositions POLNOX CORPORATION 2015-06-11 US disclosed
US-8927472-B2 Lubricant oil compositions POLNOX CORPORATION (US) 2015-01-06 US disclosed
US-20140316163-A1 NITROGEN AND HINDERED PHENOL CONTAINING DUAL FUNCTIONAL MACROMOLECULAR ANTIOXIDANTS: SYNTHESIS, PERFORMANCES AND APPLICATIONS POLNOX CORPORATION (US) 2014-10-23 US disclosed
US-20130130955-A1 LUBRICANT OIL COMPOSITIONS POLNOX CORPORATION (US) 2013-05-23 US disclosed
US-20120142968-A1 Nitrogen and Hindered Phenol Containing Dual Functional Macromolecular Antioxidants: Synthesis, Performances and Applications POLNOX CORPORATION (US) 2012-06-07 US disclosed
US-20120004150-A1 Lubricant Oil Compositions POLNOX CORPORATION 2012-01-05 US disclosed
US-8080689-B2 Nitrogen and hindered phenol containing dual functional macromolecular antioxidants: synthesis, performances and applications POLNOX CORPORATION (US) 2011-12-20 US disclosed
US-7799948-B2 stabilizers for inhibiting oxidation in organic materials, lubricants and petroleum based products, plastics and elastomers, cosmetics, foods and cooking oils POLNOX CORPORATION (US) 2010-09-21 US disclosed
US-7799948-B2 stabilizers for inhibiting oxidation in organic materials, lubricants and petroleum based products, plastics and elastomers, cosmetics, foods and cooking oils POLNOX CORPORATION (US) 2010-09-21 US disclosed
US-7705075-B2 Stabilized polyolefin compositions POLNOX CORPORATION (US) 2010-04-27 US disclosed
US-7705075-B2 Stabilized polyolefin compositions POLNOX CORPORATION (US) 2010-04-27 US disclosed
US-20080293856-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2008-11-27 US disclosed
US-20080293856-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2008-11-27 US disclosed
US-20070161522-A1 Lubricant oil compositions POLNOX CORPORATION 2007-07-12 US disclosed
US-20070161522-A1 Lubricant oil compositions POLNOX CORPORATION 2007-07-12 US disclosed
US-20070149660-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2007-06-28 US disclosed
US-20070149660-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2007-06-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140316163-A1 NITROGEN AND HINDERED PHENOL CONTAINING DUAL FUNCTIONAL MACROMOLECULAR ANTIOXIDANTS: SYNTHESIS, PERFORMANCES AND APPLICATIONS CAT, LPO, DUOX1 HSPA5 940/4885CYP2C9 1264/4885CYP2C19 1530/4885
US-20120142968-A1 Nitrogen and Hindered Phenol Containing Dual Functional Macromolecular Antioxidants: Synthesis, Performances and Applications CAT, LPO, DUOX1 HSPA5 940/4885CYP2C9 1264/4885CYP2C19 1530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.